nginx – Hosting strategies for python django rest api very light weight applications in production environment?

I am currently hosting python web services on apache server with mod_wsgi in daemon mode. Every thing is fine until, I have added a new virtualhost or changed existing virtualhost becuase when I have changed existing virtualhost or added new virtualhost the apache server will not going to recognize it directly without reloading or restarting.

So when I do graceful restart or reload of apache server to recognize new configuration all other currently requests processing daemons of mod_wsgi getting terminated forcefully as graceful is not supported by managed process of apache server where as mod_wsgi is managed process.

So, when I am changing configuration of one python web services I am facing downtime as well forceful termination of other ongoing requests. So, the above situation is not good in production environment.

At same time I want to host more no.of like around more than 200 and less than 300 very light weight python django web services

I am currently following the apache server + mod_wsgi in daemon mode in development environment but I know that it is not good or suitable for production environment as I cannot afford the downtime of other ongoing requests.

I want to know is there any another hosting strategies in which the above solutions will be resolved and also I want to deploy a large no.of very lightweight python django applications in production environment.

I know there will be strategies with containers and containers orchestration platforms but I want to know is there anything without containers?

Thankyou for your time.