helix native in cubase 12 – Helix Native

Depends on what you’re doing. Generally speaking the other user’s suggestion is correct. When recording the sound of your guitar you want Input monitoring off. 
 

But my understanding of what you are doing is that you are not recording the sound of your guitar as it enters Cubase. You want to hear the sound of your guitar, while you are playing, AFTER it is processed by Helix Native within Cubase. I don’t know if you are recording at all – seems to me you are just listening but want to hear the affected, not dry, tone. Input monitoring may provide that.

But as I mentioned before you may need to arm the track for recording even though you won’t actually record. In that case you can probably leave input monitoring off.

In any case you may notice some latency – a time lag between when you pluck your guitar string and when you hear the processed sound. This is because Helix Native needs a few milliseconds to process the incoming signal in real time.