Cubase 11 Pro Metronome only audible through certain audio interfaces – #2 by cubic13 – Cubase

Strange… I would ask you to double check the Click Options, including the Count-In one, but I guess you did that already.

What makes me wonder is that, with the Focusrite driver, no metronome sounds are hearable, so, there is a routing issue somewhere. I just checked and didn’t find, in the Preferences, something related to it. As a last resort, I would try using MIDI sounds instead, routed to a VSTi that you are sure of…

EDIT : I would also try to use the Project>Signature Track>Render Audio Clicks between Locators command : it creates instantly an audio signature track which should be hearable when playing back the project, even if the metronome is deactivated…