Native Linux Support – Page 2 – Sugar Bytes Forum

Just FYI: running wined plugins in a native host will come with a performance penalty due to context switching (depending on the amount of wine plug-in instances and the signal flow dictating the amount of required switches from the native process to the Wine process(es)).

Also, the issues surrounding Win plugins run via Wine and yabridge have been stacking up over the last years (Wine regularly breaking core functionality required by yabridge, more and more plug-ins dropping Win 7 support and updating to Win 10 APIs not supported by Wine with no plan of supporting them at all, yabridge being unmaintained for over a year).

Esp. if you strongly rely on a plug-in or need to use lots of instances, it’s good to be aware of the inherent drawbacks of wined Windows plugins so you can make the best choice for your use case.